Palladium-Catalyzed Autotandem Ring-Opening of Cyclopropanols with Gem-Dibromoolefins for the Synthesis of β-Pyrrolo[1,2-<i>a</i>]quinolinyl Ketones
Herein, the palladium-catalyzed autotandem reaction of cyclopropyl alcohols with gem-dibromoolefins is described. This reaction system involves two distinct mechanistic processes, both efficiently catalyzed by the same palladium catalyst. This approach accommodates a wide substrate scope using readily available starting materials, offering a new and efficient method for synthesizing a series of β-pyrrolo[1,2-<i>a</i>]quinolinyl ketones.
Authors
- Ping‐Xin Zhou
- Shuo Qiu (ORCID: https://orcid.org/0009-0008-4804-8640)
- Ying‐Ying Kong (ORCID: https://orcid.org/0000-0001-5027-0787)
- Qiang Wang (ORCID: https://orcid.org/0000-0001-9250-3067)
- Xueyan Du (ORCID: https://orcid.org/0000-0001-9434-8590)
- Yang Liu (ORCID: https://orcid.org/0000-0002-7240-1546)
- Yong‐Min Liang (ORCID: https://orcid.org/0000-0001-8280-8211)
Institutions
- Dongguan University of Technology (CN)
- Lanzhou University (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1021/acs.joc.4c02061
- Citations
- 7
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- Natural Science Foundation of Henan Province
- Science and Technology Department of Henan Province
- Basic and Applied Basic Research Foundation of Guangdong Province