Frequencies and mechanisms of mutational resistance to ceftibuten/avibactam in Enterobacterales
There seems little risk of ESBLs mutating to confer ceftibuten/avibactam resistance, though some risk may apply for KPC and AmpC enzymes. The propensity to select E. coli ftsI/PBP3 mutants is notable and was not seen with other avibactam combinations.
Authors
- Michel Doumith (ORCID: https://orcid.org/0000-0002-8004-0314)
- Anna Vickers
- Shazad Mushtaq (ORCID: https://orcid.org/0000-0002-3908-8332)
- Paolo Garello
- N. Woodford (ORCID: https://orcid.org/0009-0003-8867-5925)
- David M. Livermore (ORCID: https://orcid.org/0000-0002-9856-3703)
Institutions
- University of East Anglia (GB)
- UK Health Security Agency (GB)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1093/jac/dkae452
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.34
Funders
- Pfizer