Approachable, Agile, and Precise Spatial Biology with the CellScape Platform
Abstract Understanding the spatial distribution of key cell populations is critical in advancing biomedical research and the development of novel therapeutics. Highly multiplexed biomarker analysis is achieved with single-cell spatial context on the CellScape, a microscopy platform that enables quantitative spatial phenotyping of entire tissue sections mounted on standard histology slides. Leveraging high-resolution, high dynamic range imaging, and automated reagent delivery, the CellScape represents an attractive platform for spatial biology researchers from discovery to translation.
Authors
- Oliver Braubach (ORCID: https://orcid.org/0000-0003-2038-7954)
- Steven T. Lott (ORCID: https://orcid.org/0000-0001-9129-1795)
- Matthew H. Ingalls (ORCID: https://orcid.org/0000-0001-6430-9785)
- Thomas Draper Campbell
- Arne Christians
- Daniel Jiménez‐Sánchez (ORCID: https://orcid.org/0000-0002-1695-8761)
- C. S. Jackson (ORCID: https://orcid.org/0000-0002-2870-4494)
- Kayla Cashion
- Benton Berigan
- J Spencer Schwarz
- Jennifer A. Silverman
Institutions
- Bruker (United States) (US)
Publication Details
- Journal
- Microscopy Today
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1093/mictod/qaae088
- Citations
- 2
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.47