Impact of Species and Tissue Differences on In Vitro Glucuronidation of Diclofenac
This study demonstrated that the liver is the major organ for the glucuronidation of diclofenac. In addition, glucuronidation of diclofenac was different across the tested species; therefore, the influence of species should be taken into consideration in the pharmacological, pharmaceutical, and toxicological study of diclofenac.
Authors
- Dong Liang (ORCID: https://orcid.org/0000-0001-6632-8066)
- Huan Xie (ORCID: https://orcid.org/0000-0002-0591-5619)
- Ting Du (ORCID: https://orcid.org/0000-0002-7705-6913)
- Song Gao (ORCID: https://orcid.org/0000-0003-2361-3494)
- Eric Asare (ORCID: https://orcid.org/0009-0008-5621-7109)
- Shalom Emmanuel (ORCID: https://orcid.org/0009-0000-5190-1472)
Institutions
- Texas Southern University (US)
Publication Details
- Journal
- Molecules
- Published
- 2024-12-12
- DOI
- https://doi.org/10.3390/molecules29245867
- Citations
- 3
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 1.34
Funders
- Cancer Prevention and Research Institute of Texas
- National Institute of General Medical Sciences
- National Institute on Minority Health and Health Disparities