Age-related remodeling of the vocal fold extracellular matrix composition, structure, and biomechanics during tissue maturation
This work identifies changes in VF ECM composition and organization during tissue maturation, focusing on proteins that regulate collagen fibrillogenesis, fiber assembly, and VF biomechanics. These findings may inform the development of pro-reparative therapies designed to influence collagen network structure and overall ECM dysregulation in a number of laryngeal pathologies.
Authors
- Karen B. Zur (ORCID: https://orcid.org/0000-0002-9045-6559)
- Elizabeth Brown (ORCID: https://orcid.org/0000-0001-7983-5868)
- Neil Patel (ORCID: https://orcid.org/0000-0002-4702-8583)
- Riccardo Gottardi (ORCID: https://orcid.org/0000-0001-8040-5531)
- Matthew R. Aronson (ORCID: https://orcid.org/0000-0002-8871-8265)
- Lin Han (ORCID: https://orcid.org/0000-0003-4180-1288)
- Ryan M. Friedman
- Arielle S. Breuninger
Institutions
- Children's Hospital of Philadelphia (US)
- Ri.MED (IT)
- Drexel University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Connective Tissue Research
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1080/03008207.2024.2435364
- Citations
- 5
- Primary Topic
- Voice and Speech Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- National Science Foundation
- University of Pennsylvania
- Drexel University