Experimental studies of biodegradable ureteral stent prototype

Degradable ureteral stent not requiring redo procedure for removal is an important issue in modern urology. This device could solve the problem of «forgotten stent» often leading to long-term complications. The authors describe the prototype of biodegradable ureteral stent based on poly(L-lactide-co-ε-caprolactone) and present the first results of its testing. Characteristics of synthesized polymer meet the requirements in medicine. Tests of rod-shaped stent prototypes showed that material has sufficient strength and elasticity. Analysis of stent degradation in artificial urine environment at 37 ºC showed that it retains strength for at least 2 weeks. No suppression of cell growth confirms no cellular toxicity. New material based on poly(L-lactide-co-ε-caprolactone) is promising for development of experimental samples of biodegradable ureteral stents and further <i>in vivo</i> testing.