Characterization of metabolic profile of Dazhu Hongjingtian and evaluation of its anti-hypoxic constituents
Dazhu Hongjingtian (DZ) is renowned for its diverse pharmacological activities, yet its metabolic pathways remain to be fully elucidated. In this study, the metabolic profile after oral administration of DZ extract (DZE) in rats was systematically identified by the UPLC/Q-TOF-MS/MS method for the first time. A total of 94 components, including 32 prototypes and 62 metabolites, were tentatively characterized in rat plasma and various tissues samples. Furthermore, 6 constituents (salidroside, quercetin, 4-hydroxycinnamic acid, 5-hydroxymethylfurfural, <i>p</i>-tyrosol, and gallic acid) derived from plasma prototypes were identified as bioactive by assessing cell viabilities of OGD-injured RSC96 cells.
Authors
- Chunyan Ou
- Liang Cao (ORCID: https://orcid.org/0000-0001-7293-8338)
- Xialin Chen (ORCID: https://orcid.org/0000-0001-7589-7957)
- Xia Gao
- Jiajia Wang (ORCID: https://orcid.org/0000-0002-8177-3915)
- Wei Xiao (ORCID: https://orcid.org/0000-0001-8809-9137)
- Zhenzhong Wang (ORCID: https://orcid.org/0000-0002-1364-3537)
- Chenfeng Zhang
Institutions
- Nanjing University of Chinese Medicine (CN)
- Kanion Pharmaceutical (China) (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1080/10286020.2024.2434550
- Primary Topic
- Medicinal Plants and Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00