Increased EBNA1-specific antibody response in primary-progressive multiple sclerosis
Elevated immune responses toward EBNA1 are selectively increased in people with primary progressive disease, indicating a link between EBNA1-targeting immune responses and the development of both RMS and PPMS. Our data also suggest that chronic HCMV infection is associated with progressive MS.
Authors
- Neus Mongay‐Ochoa (ORCID: https://orcid.org/0000-0002-0338-4797)
- Jan Lycke (ORCID: https://orcid.org/0000-0002-7891-8466)
- Sara Llufriú (ORCID: https://orcid.org/0000-0003-4273-9121)
- Igal Rosenstein (ORCID: https://orcid.org/0000-0002-5078-9690)
- Harald Hegen
- Jan D. Lünemann (ORCID: https://orcid.org/0000-0002-3007-708X)
- Jaume Sastre‐Garriga (ORCID: https://orcid.org/0000-0002-1589-2254)
- Hayrettin Tumani (ORCID: https://orcid.org/0000-0002-1647-6201)
- Francisco Pérez‐Miralles (ORCID: https://orcid.org/0000-0003-3767-3738)
- Roberto Álvarez‐Lafuente (ORCID: https://orcid.org/0000-0002-3132-1486)
- Xavier Montalbán (ORCID: https://orcid.org/0000-0002-0098-9918)
- Tamara Castillo‐Triviño (ORCID: https://orcid.org/0000-0002-9249-3185)
- Ahmed Abdelhak (ORCID: https://orcid.org/0000-0001-9731-4169)
- David Otaegui (ORCID: https://orcid.org/0000-0002-6625-5976)
- Antonio Sánchez (ORCID: https://orcid.org/0000-0001-7168-6175)
- Pere Carbonell‐Mirabent (ORCID: https://orcid.org/0000-0003-1349-9261)
- Enric Monreal (ORCID: https://orcid.org/0000-0003-3293-0125)
- Augusto Sao‐Avilés
- Malina Behrens
- Adrián Valls Carbó (ORCID: https://orcid.org/0000-0002-4831-1276)
- Konrad Rejdak (ORCID: https://orcid.org/0000-0002-7019-6681)
- Nicolás Fissolo (ORCID: https://orcid.org/0000-0002-7701-9346)
- Sergio Martínez‐Yélamos (ORCID: https://orcid.org/0000-0001-9889-2040)
- Javier Villacieros‐Álvarez (ORCID: https://orcid.org/0000-0002-5443-1434)
- Luisa María Villar (ORCID: https://orcid.org/0000-0002-9067-3668)
- Franziska Bachhuber (ORCID: https://orcid.org/0000-0003-1031-9966)
- Klaus Berek (ORCID: https://orcid.org/0000-0003-2755-2043)
- Manuel Comabella (ORCID: https://orcid.org/0000-0002-2373-6657)
- Yolanda Blanco (ORCID: https://orcid.org/0000-0002-1834-0498)
- Lucía Gutiérrez (ORCID: https://orcid.org/0000-0001-7312-7254)
- Heinz Wiendl (ORCID: https://orcid.org/0000-0001-5509-1075)
- Antonio Garcı́a-Merino
Institutions
- Medical University of Lublin (PL)
- Universitat Autònoma de Barcelona (ES)
- Innsbruck Medical University (AT)
- University of California, San Francisco (US)
- Universidad de Alcalá (ES)
- Universität Innsbruck (AT)
- Universität Ulm (DE)
- Instituto de Salud Carlos III (ES)
- Bellvitge University Hospital (ES)
- Hospital Clínico San Carlos (ES)
- Hospital Universitari i Politècnic La Fe (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (ES)
- Biogipuzkoa Health Research Institute (ES)
- Vall d'Hebron Institut de Recerca (ES)
- University Hospital Münster (DE)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Hospital Universitario Ramón y Cajal (ES)
- Universitat de Barcelona (ES)
- University of Gothenburg (SE)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1007/s00415-024-12763-w
- Citations
- 7
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.97
Funders
- European Commission
- HORIZON EUROPE Framework Programme