Macroencapsulation Device with Anti-inflammatory Membrane Modification Enhances Long-Term Viability and Function of Transplanted β Cells
Treating type 1 diabetes (T1D) through β-cell macroencapsulation is a promising long-term solution, but it faces challenges such as immune-mediated fibrosis on the capsule surface, which impairs cell functionality and compromises longevity and effectiveness. This study presents an approach for including an anti-inflammatory molecule on the macroencapsulation device (MED) using initiated chemical vapor deposition for the surface modification of poly(tetrafluoroethylene) (PTFE) membranes. The surface-modified MEDs significantly reduced fibrosis, improved β-cell viability and functionality, and promoted M2 macrophage polarization, which is associated with anti-inflammatory effects. This MED displayed improved glycemic control in a streptozotocin-induced diabetic mouse model for 45 days. The findings underscore the potential of surface-modified MEDs for improving T1D management by mitigating inflammation and enhancing the therapeutic efficacy of β-cell encapsulation.
Authors
- Sung Han Shim (ORCID: https://orcid.org/0000-0002-9814-5448)
- Kisuk Yang (ORCID: https://orcid.org/0000-0002-2724-5222)
- Hyejeong Seong (ORCID: https://orcid.org/0000-0002-9877-296X)
- Sophie S. Liu (ORCID: https://orcid.org/0000-0002-6616-1339)
- Hyun‐Do Jung (ORCID: https://orcid.org/0000-0001-8632-7431)
- Younghak Cho (ORCID: https://orcid.org/0000-0002-7603-2063)
- Jung-Eun Lee (ORCID: https://orcid.org/0000-0003-4105-2600)
- Hyun Ho Lee (ORCID: https://orcid.org/0000-0002-3935-5437)
- Minji Park (ORCID: https://orcid.org/0009-0003-9815-0495)
- Yerim Jang
- Min Ji Kim
Institutions
- Incheon National University (KR)
- University of Toronto (CA)
- Korea University (KR)
- Korea Institute of Brain Science (KR)
- Division of Materials Science and Engineering (AU)
- Korean Association Of Science and Technology Studies (KR)
- Bioengineering Center (RU)
- Bio-Medical Science (South Korea) (KR)
- Materials Technology (United Kingdom) (GB)
- PRG S&Tech (South Korea)
- Hanyang University (KR)
- Korea Institute of Science and Technology (KR)
- Korea University of Science and Technology (KR)
- Korea Institute of Industrial Technology (KR)
Publication Details
- Journal
- ACS Applied Materials & Interfaces
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1021/acsami.4c14057
- Citations
- 2
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Ministry of Health and Welfare
- Korea Institute of Science and Technology
- Ministry of Science and ICT, South Korea