Enantioselective synthesis of a new styryl lactone 9 deoxygoniopypyrone derivative and its antiproliferative activity

We report the enantioselective synthesis of a novel styryl lactone using a versatile Chiron derived from Dglucose under mild conditions.The synthesis is carried out in four steps with an overall yield of 57%.The change of the phenyl functional group by an allyl group was performed to analyze the effects that this modification causes on cytotoxicity in mouse breast cancer cell lines (Ep-H4-EV, 67NR,66cl4 and 4T1) in comparison with 9-deoxygoniopipyrone from a natural source, observing an increase in selectivity.The findings suggest potential pathways for further structural modifications to enhance the anticancer properties of these compounds.The results pave the way for developing new derivatives of 9-deoxygoniopypyrone for in vitro cancer research.