Parkin deficiency aggravates inflammation-induced acute lung injury by promoting necroptosis in alveolar type II cells
These findings underscore the multifaceted role of Parkin in the progression of lung injury, inflammation, and fibrosis through the regulation of AT2 cell necroptosis. Therefore, Parkin may hold potential as a therapeutic target for managing lung injury and fibrosis.
Authors
- Linglong Yang
- Meiyu Quan
- Quan Li (ORCID: https://orcid.org/0000-0003-0058-2672)
- Xuru Jin
- Jin‐San Zhang (ORCID: https://orcid.org/0000-0002-4436-9593)
- Chenhua Yu
- Qiang Guo (ORCID: https://orcid.org/0000-0001-5403-0692)
- Zhenkun Lou (ORCID: https://orcid.org/0000-0003-1938-3091)
- Jiaqi Li (ORCID: https://orcid.org/0009-0005-4613-5116)
- Junjie Chen (ORCID: https://orcid.org/0009-0005-2665-1279)
- Bin Liu (ORCID: https://orcid.org/0000-0001-5574-3547)
- Dong Li (ORCID: https://orcid.org/0000-0002-0331-6022)
- Yuting Zhang (ORCID: https://orcid.org/0000-0002-2171-2096)
- Chengshui Chen (ORCID: https://orcid.org/0000-0003-4841-9911)
- Xihua Yan
- Qigang Weng
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Mayo Clinic in Arizona (US)
Publication Details
- Journal
- Chinese Medical Journal - Pulmonary and Critical Care Medicine
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1016/j.pccm.2024.11.004
- Citations
- 4
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.55