Adverse Effects of Oral Administration of Bisphenol A-Induced Toxicity on Adult Male Rat Liver and Testis With the Protective Roles of Herbal Teas

Bisphenol A (BPA) is a monomer widely used in our living environment to manufacture many chemical products. Mammalian cells are exposed to it at high levels, which has toxic and estrogenic consequences. Moreover, BPA exposure during prenatal and neonatal development results in defects in the male and female reproductive systems, abnormal meiotic development in fetal oocytes, and pregnancy complications. The principle of the current study was to study the adverse effects of the oral administration of BPA on the liver and testis toward adult male rats with the protective roles of herbal teas. A comparative study was conducted on 40 adult rats. Groups were coded as RT/BPA, GT/BPA, and BT/BPA, for red, green, and blue herbal teas, respectively. lowest values for AST (58.71 mU/mL), ALP (1.51 mU/mL), and GGT (21.12 U/L). Similarly, RT/BPA and BT/BPA groups were detected (4.11 and 4.12 mg/100 mL) for creatinine levels as compared to the vehicle control group. While rats in BT/BPA and GT/BPA groups showed similar values to the vehicle group (45.02 and 118.28 mg/dI) for HDL and TC quantities, respectively. The present research work established the protecting rolls of herbal teas due to the antioxidant properties especially green tea which preserved GPx value (88.22 nmol/mg), testosterone (1.80 ng/ml), and red tea which preserved CAT value (101.18 U/mg), while blue tea preserved MDA and SOD values (0.81 nmol/mg and 7.18 U/mg), respectively. The BPA oral administration with herbal teas reduced toxicity on the liver and testis due to free radical scavenging effects.