Non-lytic spread of poliovirus requires the nonstructural protein 3CD
Poliovirus (PV) and other enteroviruses hijack the cellular secretory autophagy pathway for non-lytic virus transmission. While much is known about the cellular factors required for non-lytic transmission, much less is known about viral factors contributing to transmission. We have discovered a PV nonstructural protein required for multiple steps of the pathway leading to vesicle-enclosed virions. This discovery should facilitate the identification of the specific steps of the cellular secretory autophagy pathway and corresponding factors commandeered by the virus and may uncover novel targets for antiviral therapy.
Authors
- Neela H. Yennawar (ORCID: https://orcid.org/0000-0001-7278-659X)
- Craig E. Cameron (ORCID: https://orcid.org/0000-0002-7564-5642)
- Ibrahim M. Moustafa (ORCID: https://orcid.org/0000-0002-5122-7569)
- Andrew Macadam (ORCID: https://orcid.org/0000-0002-8687-1573)
- Jennifer L. Gray (ORCID: https://orcid.org/0000-0003-4173-3916)
- Tongjia Ella Kang (ORCID: https://orcid.org/0000-0003-1613-9608)
- Mohamad S. Sotoudegan (ORCID: https://orcid.org/0000-0002-1293-8739)
- Victoria Korboukh
- David Aponte-Diaz (ORCID: https://orcid.org/0000-0002-6023-2036)
- J Harris (ORCID: https://orcid.org/0000-0002-4682-1766)
Institutions
- University of North Carolina at Chapel Hill (US)
- Pennsylvania State University (US)
Publication Details
- Journal
- mBio
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1128/mbio.03276-24
- Citations
- 3
- Primary Topic
- Plant Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.80
Funders
- Burroughs Wellcome Fund
- University of Pennsylvania
- Pennsylvania State University
- National Institutes of Health
- Huck Institutes of the Life Sciences
- National Institute of Allergy and Infectious Diseases
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill