Detecting Colorectal Neoplasia Using Specific Fecal Fluorogenic Protease-Sensitive Substrates: A Pilot Study
we successfully developed colorectal neoplasia-specific fluorogenic substrates, highlighting the ED substrate as a potential substrate for the detection of AA and CRC. Although the responsible proteases require further identification, our results suggest an association with calcium-dependent cysteine proteases.
Authors
- Nanne K.H. de Boer (ORCID: https://orcid.org/0000-0001-8357-9887)
- Floris J. Bikker (ORCID: https://orcid.org/0000-0002-9453-4630)
- Roza C.M. Opperman (ORCID: https://orcid.org/0000-0002-7279-0940)
- Sofie Bosch (ORCID: https://orcid.org/0000-0001-9202-1674)
- Wendy E. Kaman (ORCID: https://orcid.org/0000-0002-0159-2816)
- Evelien Dekker (ORCID: https://orcid.org/0000-0002-4363-0745)
- H.S. Brand (ORCID: https://orcid.org/0000-0002-7829-9116)
- Connie R. Jiménez (ORCID: https://orcid.org/0000-0002-3103-4508)
- Kamran Nazmi (ORCID: https://orcid.org/0000-0001-9868-2959)
- Tim G. J. de Meij
Institutions
- Academic Center for Dentistry Amsterdam (NL)
- Emma Kinderziekenhuis (NL)
- Amsterdam University Medical Centers (NL)
- Cancer Center Amsterdam (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Analytical Chemistry
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1021/acs.analchem.4c04586
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Teva Pharmaceutical Industries