Axillary Surgery in Breast Cancer — Primary Results of the INSEMA Trial
In this trial involving patients with clinically node-negative, T1 or T2 invasive breast cancer (90% with clinical T1 cancer and 79% with pathological T1 cancer), omission of surgical axillary staging was noninferior to sentinel-lymph-node biopsy after a median follow-up of 6 years. (Funded by the German Cancer Aid; INSEMA ClinicalTrials.gov number, NCT02466737.).
Authors
- Roland Reitsamer (ORCID: https://orcid.org/0000-0001-6330-2653)
- Johannes Holtschmidt (ORCID: https://orcid.org/0000-0002-2723-1154)
- Frederik Marmé (ORCID: https://orcid.org/0000-0002-6591-3367)
- Michael Knauer (ORCID: https://orcid.org/0000-0002-6266-9194)
- Thorsten Kühn
- Beyhan Ataseven (ORCID: https://orcid.org/0000-0002-2823-7590)
- Silke Polata
- Carsten Denkert (ORCID: https://orcid.org/0000-0002-2249-0982)
- Inga Bekes
- David A. Krug (ORCID: https://orcid.org/0000-0001-8811-5416)
- Toralf Reimer (ORCID: https://orcid.org/0000-0003-3014-370X)
- Marc Thill (ORCID: https://orcid.org/0000-0002-8800-8044)
- Valentina Nekljudova (ORCID: https://orcid.org/0000-0002-2801-7387)
- Kristina Veselinovic (ORCID: https://orcid.org/0000-0002-2959-0580)
- Sylvia Ruth
- Michael Golatta (ORCID: https://orcid.org/0000-0002-2605-0060)
- Sibylle Loibl
- Guido Hildebrandt (ORCID: https://orcid.org/0000-0002-0498-2692)
- Angrit Stachs (ORCID: https://orcid.org/0000-0002-6035-130X)
- Joerg Heil (ORCID: https://orcid.org/0000-0002-4684-9099)
- Thomas Müller (ORCID: https://orcid.org/0000-0001-8726-6052)
- Bernd Gerber
- Dirk-Michael Zahm
Institutions
- Universität Hamburg (DE)
- Philipps University of Marburg (DE)
- University of Mannheim (DE)
- Heidelberg University (DE)
- Kantonsspital St. Gallen (CH)
- University Hospital Heidelberg (DE)
- Klinikum Hanau (DE)
- SRH Wald-Klinikum Gera (DE)
- St. Elisabeth-Hospital Bochum (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- University Hospital Schleswig-Holstein (DE)
- Klinikum Esslingen (DE)
- Breast Center (CH)
- Klinikum Lippe (DE)
- German Breast group (DE)
- Klinikum Bielefeld (DE)
- Waldkrankenhaus Protestant Hospital (DE)
- Unfallkrankenhaus Salzburg (AT)
- Agaplesion Markus Hospital (DE)
- Hochschule Magdeburg-Stendal (DE)
- University Hospital Ulm (DE)
- University Medical Centre Mannheim (DE)
- University of Rostock (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1056/nejmoa2412063
- Citations
- 190
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 54.18
Funders
- Deutsche Krebshilfe