Facile construction of distal and diversified tertiary and quaternary stereocenters

Exploration of novel chiral pharmaceutical candidates is motivation to immersive efforts among synthetic chemists. Achieving skeletal construction and chiral diversity in a highly efficient manner is a momentous goal in the chemical society. Unfortunately, current methods for chiral induction focus primarily on a specific site. Herein, we realized the asymmetric chain-walking arylation of alkenyl alcohols for the construction of multisite tertiary and quaternary stereocenters in high yields and enantioselectivity. This new operation-friendly strategy carries substantial potential for future industrialization.