Investigating the Impact of Glycogen-Depleting Exercise Combined with Prolonged Fasting on Autophagy and Cellular Health in Humans: A Randomised Controlled Crossover Trial
While autophagic flux induction through fasting has garnered interest, there is a notable lack of human studies on this topic. This trial aims to provide the most detailed and integrated analysis of how three days of prolonged water-only fasting, combined with glycogen-depleting exercise, affects autophagy activation and other crucial metabolic and molecular pathways linked to cellular, metabolic, and immune health. Insights from this study may pave the way for safe and effective strategies to induce autophagy, offering potential preventive interventions for a range of chronic conditions.
Authors
- Cynthia M. Kroeger (ORCID: https://orcid.org/0000-0002-5828-4283)
- Leanne K. Hein (ORCID: https://orcid.org/0000-0001-5887-7858)
- Andrius Masedunskas (ORCID: https://orcid.org/0000-0002-4533-5467)
- David K. Hutchinson (ORCID: https://orcid.org/0000-0001-9385-4782)
- Luigi Fontana (ORCID: https://orcid.org/0000-0001-8500-5537)
- Laura Piccio (ORCID: https://orcid.org/0000-0002-8760-109X)
- Lara Rogerson‐Wood
- Angelo Sabag (ORCID: https://orcid.org/0000-0002-0195-7029)
- Timothy J. Sargeant (ORCID: https://orcid.org/0000-0003-1254-4390)
- Yvonne Kong (ORCID: https://orcid.org/0000-0002-1972-0441)
- Freda Passam (ORCID: https://orcid.org/0000-0003-4584-2044)
- María Lastra Cagigas (ORCID: https://orcid.org/0000-0001-5464-2349)
- Anjie Ge (ORCID: https://orcid.org/0000-0002-1027-2793)
- Isabella De Ciutiis
- Drishya Mainali (ORCID: https://orcid.org/0009-0006-4278-1046)
- Tian Wang (ORCID: https://orcid.org/0000-0001-7217-4200)
- Miao Qi (ORCID: https://orcid.org/0000-0001-9620-0055)
- Yvonne Aguirre Candia
Institutions
- The University of Sydney (AU)
- Royal Prince Alfred Hospital (AU)
- South Australian Health and Medical Research Institute (AU)
- The University of Adelaide (AU)
Publication Details
- Journal
- Nutrients
- Published
- 2024-12-12
- DOI
- https://doi.org/10.3390/nu16244297
- Citations
- 2
- Primary Topic
- Dietary Effects on Health
- Type
- article
- Field-Weighted Citation Impact
- 0.65
Funders
- Bakewell Foundation
- Australian Youth and Health Foundation
- National Health and Medical Research Council