Induction triplet chemotherapy in patients with rectal adenocarcinoma and synchronous metastases, an AGEO-FFCD study
The management of metastatic rectal cancer is essentially based on three main therapeutic approaches: surgery, radiotherapy/chemoradiotherapy and chemotherapy. Induction triplet chemotherapy appears as a good choice for fit and young patients. It allows to adapt the therapeutic strategy to the response and invasiveness of the various sites. In this study dedicated to patients undergoing treatment for rectal cancer with synchronous metastases, FOLFIRINOX-based induction chemotherapy was associated with objective response rate of 77% and disease control rate of 92%. These results are similar with those of the FFCD 1102 trial and confirm the efficacy of induction chemotherapy with FOLFIRINOX with or without targeted therapy in these patients in daily routine practice. Surgery for metastases is a key factor in determining patient's outcome and triplet induction chemotherapy, associated with high response rates, enables a significant percentage of patients to undergo surgery and appears therefore to be a treatment of choice, particularly for patients whose disease is unresectable at baseline.
Authors
- Victoire Dabout
- Claire Gallois (ORCID: https://orcid.org/0000-0003-2369-7341)
- Marie Porte (ORCID: https://orcid.org/0000-0002-6889-3779)
- Karine Le Malicot (ORCID: https://orcid.org/0000-0002-3226-8525)
- Côme Lepage (ORCID: https://orcid.org/0000-0001-9211-4707)
- Anthony Turpin (ORCID: https://orcid.org/0000-0002-2282-0101)
- Marine Valéry (ORCID: https://orcid.org/0000-0002-7787-6911)
- Romain Cohen (ORCID: https://orcid.org/0000-0001-9602-5162)
- Vincent Hautefeuille (ORCID: https://orcid.org/0000-0003-2735-6448)
- Gilles Breysacher
- Jean–Marc Phelip (ORCID: https://orcid.org/0000-0002-4232-6039)
- Jean‐Baptiste Bachet (ORCID: https://orcid.org/0000-0003-4337-286X)
- Laurent Mineur (ORCID: https://orcid.org/0000-0003-4615-4358)
- Thierry Lecomte (ORCID: https://orcid.org/0000-0001-5093-0212)
- Fabien Brocard
- Bénédicte Demoustier (ORCID: https://orcid.org/0000-0002-0213-2336)
- David Tougeron
- Emmanuel Mitry
- Christophe Locher
- Jean-Paul Lagasse
- Déborah Hassid
- Charles-Briac Levaché
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Lille (FR)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Centre Hospitalier Universitaire Amiens-Picardie (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre Hospitalier Universitaire de Poitiers (FR)
- Fédération Francophone de Cancérologie Digestive (FR)
- Hôpital Pasteur (FR)
- Hôpital Saint-Louis (FR)
- Institut Paoli-Calmettes (FR)
- Institut Sainte Catherine (FR)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- Clinics and Research in Hepatology and Gastroenterology
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1016/j.clinre.2024.102514
- Citations
- 1
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.28