Low thrombin inactivation capacity is associated with an increased risk of recurrent ischemic events after ischemic stroke at a young age
After an ischemic stroke or TIA at a young age, the thrombin decay constant, which reflects reduced protection against thrombin (low antithrombin) and decreased potential to inhibit thrombin (high fibrinogen), is associated with recurrent ischemic events.
Authors
- Saskia Middeldorp (ORCID: https://orcid.org/0000-0002-1006-6420)
- Anil M. Tuladhar (ORCID: https://orcid.org/0000-0002-4815-2834)
- Marleen M. H. J. van Gelder (ORCID: https://orcid.org/0000-0003-4853-4434)
- Janneke Spiegelenberg (ORCID: https://orcid.org/0000-0003-4766-3322)
- Mark Roest (ORCID: https://orcid.org/0000-0002-7349-7068)
- Jenneke Leentjens (ORCID: https://orcid.org/0000-0003-3356-3910)
- Bas de Laat
- Frank-Erik de Leeuw
- Romy de Laat‐Kremers
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- Synapse (Netherlands) (NL)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1016/j.jtha.2024.12.002
- Citations
- 3
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.36