Development and Characterization of Novel Combinations and Compositions of Nanostructured Lipid Carrier Formulations Loaded with Trans-Resveratrol for Pulmonary Drug Delivery
Overall, formulation F14 in combination with an air-jet nebulizer was identified as a superior combination, demonstrating higher emitted dose (ED; 80%), fine particle dose (FPD; 1150 µg), fine particle fraction (FPF; 24%), and respirable fraction (RF; 94%). These findings are promising in the optimization and development of NLC formulations, highlighting their versatility and targeting the pulmonary system via nebulization.
Authors
- Huner K. Omer (ORCID: https://orcid.org/0000-0003-1161-5257)
- Sakib Yousaf
- Nozad Hussein (ORCID: https://orcid.org/0000-0001-6920-8270)
- Hassaan Anwer Rathore (ORCID: https://orcid.org/0000-0002-1154-9395)
- Iftikhar Khan (ORCID: https://orcid.org/0000-0002-4206-7663)
- Chahinez Houacine (ORCID: https://orcid.org/0000-0002-7977-2569)
- Wasiq Khan (ORCID: https://orcid.org/0000-0002-7511-3873)
- Sunita Sunita
- Abdelbary Elhissi
Institutions
- Hawler Medical University (IQ)
- University of Lancashire (GB)
- Qatar University (QA)
- Liverpool John Moores University (GB)
Publication Details
- Journal
- Pharmaceutics
- Published
- 2024-12-12
- DOI
- https://doi.org/10.3390/pharmaceutics16121589
- Citations
- 8
- Primary Topic
- Inhalation and Respiratory Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 3.35
Funders
- Qatar University