circUBR5 promotes ribosome biogenesis and induces docetaxel resistance in triple-negative breast cancer cell lines via the miR-340-5p/CMTM6/c-MYC axis
circUBR5 knockdown facilitated miR-340-5p-targeted CMTM6 via a ceRNA mechanism, thereby reducing c-MYC-mediated ribosome biogenesis and accelerating chemosensitization of DTX-resistant TNBC cells, which offered a theoretical guideline for clinical research on the feasibility of inhibiting ribosome biogenesis to reduce TNBC chemoresistance.
Authors
- Yue Wei (ORCID: https://orcid.org/0000-0002-9922-3479)
- Xuedong Wang (ORCID: https://orcid.org/0000-0002-4439-5871)
- Juan Gu (ORCID: https://orcid.org/0000-0001-8723-1044)
- Xinping Wang (ORCID: https://orcid.org/0009-0007-6090-2830)
- Yueping Wang (ORCID: https://orcid.org/0000-0002-2668-854X)
Institutions
- Anhui University (CN)
- Anhui University of Science and Technology (CN)
- Anhui Provincial Hospital (CN)
Publication Details
- Journal
- Neoplasia
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1016/j.neo.2024.101062
- Citations
- 3
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.70