Systematic Evaluation of HILIC Stationary Phases for MS Characterization of Oligonucleotides
Hydrophilic interaction chromatography–mass spectrometry (HILIC-MS) offers a flexible and efficient alternative to ion-pairing reversed-phase liquid chromatography (IP-RPLC) for oligonucleotide analysis, with column selectivity and mobile phase pH being key factors in optimizing retention and detection.
Authors
- Ta-Chen Wei (ORCID: https://orcid.org/0000-0002-0953-6237)
- Alex Apffel
- Antonio Tripodi (ORCID: https://orcid.org/0000-0002-5214-6680)
- Clare A. Flannery (ORCID: https://orcid.org/0000-0002-0219-0907)
- Andrew F. Coffey
- Jordy J. Hsiao (ORCID: https://orcid.org/0000-0002-2487-5034)
- Lee J. Bertram
Institutions
- Agilent Technologies (Germany) (DE)
Publication Details
- Journal
- LCGC International
- Published
- 2024-10-01
- DOI
- https://doi.org/10.56530/lcgc.int.ij3573k8
- Citations
- 3
- Primary Topic
- Mass Spectrometry Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.72