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Compaction of the genome affects the initial yield of strand breaks. Some radiosensitivity differences between cell lines can be attributed to genome compaction changes between the phases of the cell cycle. This study provides a basis for further analysis of how repair deficiencies impact radiation-induced lethality in normal and malignant cells.
Authors
- A. Chambers (ORCID: https://orcid.org/0000-0001-8133-6240)
- J. J. Velthuis (ORCID: https://orcid.org/0000-0002-4649-3221)
- D. Sakata (ORCID: https://orcid.org/0000-0002-8398-3334)
- Chiara De Sio (ORCID: https://orcid.org/0000-0001-9112-425X)
- Mark S. Dillingham (ORCID: https://orcid.org/0000-0002-4612-7141)
- Yuyao Shi (ORCID: https://orcid.org/0000-0002-4339-7816)
- Anatoly Rosenfeld (ORCID: https://orcid.org/0000-0001-5116-6308)
- Susanna Guatelli (ORCID: https://orcid.org/0000-0002-9289-7956)
- L. Beck (ORCID: https://orcid.org/0000-0003-4369-7648)
- Laura Ballisat (ORCID: https://orcid.org/0000-0003-2541-4464)
- Jinyan Duan
Institutions
- University of Wollongong (AU)
- At Bristol (GB)
- University of Bristol (GB)
Publication Details
- Journal
- Physica Medica
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1016/j.ejmp.2024.104871
- Citations
- 1
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- UK Research and Innovation
- Cancer Research UK
- University of Bristol
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- Cancer Research UK Cambridge Institute, University of Cambridge