Rapid Recovery From SARS-CoV-2 Infection Among Immunocompromised Children Despite Limited Neutralizing Antibody Response: A Virologic and Sero-Immunologic Analysis of a Single-Center Cohort
IC pediatric patients rapidly recovered from COVID-19 with low viral loads. Antibody response was limited, but cytokine analysis suggested an enhanced IFN-γ- and IL-18-mediated immune response without excessive activation of inflammatory cascades. To validate our observation, immune cell-based functional studies need to be conducted among IC and non-IC children.
Authors
- Tae Yeul Kim (ORCID: https://orcid.org/0000-0002-6405-5305)
- Areum Shin (ORCID: https://orcid.org/0000-0003-3341-0447)
- Byoung Kwon Park
- Hee Won Cho (ORCID: https://orcid.org/0000-0002-0440-645X)
- Hee Young Ju (ORCID: https://orcid.org/0000-0001-6744-0412)
- Ki Woong Sung (ORCID: https://orcid.org/0000-0001-5989-4772)
- Keon Hee Yoo (ORCID: https://orcid.org/0000-0002-5980-7912)
- Doo Ri Kim (ORCID: https://orcid.org/0000-0001-5233-4043)
- Yae‐Jean Kim (ORCID: https://orcid.org/0000-0002-8367-3424)
- June‐Young Koh (ORCID: https://orcid.org/0000-0002-2043-6624)
- Chae-Hong Jeong (ORCID: https://orcid.org/0000-0001-6863-7575)
- Jin Yang Baek (ORCID: https://orcid.org/0000-0002-2117-710X)
- Ji Won Lee (ORCID: https://orcid.org/0000-0003-0084-1304)
- Jae‐Hoon Ko (ORCID: https://orcid.org/0000-0002-9490-6609)
Institutions
- Genomatica (United States) (US)
- Samsung (South Korea) (KR)
- Samsung Medical Center (KR)
- Korea Disease Control and Prevention Agency (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Journal of Korean Medical Science
- Published
- 2024-12-12
- DOI
- https://doi.org/10.3346/jkms.2025.40.e52
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Korea Disease Control and Prevention Agency
- Samsung
- Korea National Institute of Health
- Korea Institute of Materials Science