PF-477736 modulates vascular smooth muscle cells phenotypic transition through Chk1/p53/CD44 pathway
Our findings show that PF-477736 exerts anti-vascular remodeling effect by inhibiting phenotypic transition through the Chk1/p53/CD44 pathway in VSMCs, providing novel therapeutic strategies for preventing and treating vascular remodeling.
Authors
- Yu Lv
- Fangqin Nie
- Zizhao Tang
- Youjie Zeng (ORCID: https://orcid.org/0000-0003-3842-1815)
- Ren Guo (ORCID: https://orcid.org/0000-0002-3930-6846)
- Xia Wang (ORCID: https://orcid.org/0000-0002-4569-8778)
Institutions
- Central South University (CN)
- Zunyi Medical University (CN)
- First Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
- First People’s Hospital of Zunyi (CN)
- Third Xiangya Hospital (CN)
Publication Details
- Journal
- Tissue and Cell
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1016/j.tice.2024.102682
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Natural Science Foundation of Hunan Province