Analysis of differentially methylated sites and regions associated with intrauterine transmission of hepatitis B virus in infants
Prenatal HBV exposure was associated with significant infant hypomethylation, particularly in regulatory regions like TSS1500, TSS200, and CpG islands, potentially impacting gene expression. Enrichment of immune-related pathways among differentially methylated genes suggests that HBV may alter infant immune development through epigenetic modifications.
Authors
- Kai Shao (ORCID: https://orcid.org/0000-0003-0613-4862)
- Xixi Shen (ORCID: https://orcid.org/0000-0002-5824-6762)
- Shiyue Zhang (ORCID: https://orcid.org/0009-0001-5313-9802)
- Dan Luo (ORCID: https://orcid.org/0000-0002-4657-6131)
- Hai Li
- Jiawei Zhang (ORCID: https://orcid.org/0000-0002-5782-5543)
- Shiyi Chen (ORCID: https://orcid.org/0000-0001-9190-3122)
- Jialing Li (ORCID: https://orcid.org/0000-0003-1827-9313)
- Zhiguang Su (ORCID: https://orcid.org/0000-0001-8635-9310)
- Ting Zeng (ORCID: https://orcid.org/0000-0001-6041-4211)
- Liping Hu
- Yongjian Su (ORCID: https://orcid.org/0009-0009-1750-0427)
- Xiaojing Guo
Institutions
- Guangxi University (CN)
- Liuzhou Maternal and Child Health Hospital (CN)
- Guangxi University of Chinese Medicine (CN)
- Zhongshan Hospital (CN)
- Guangxi Center for Disease Prevention and Control (CN)
- Ruikang Affiliated Hospital of Guangxi Medical University (CN)
Publication Details
- Journal
- Infection Genetics and Evolution
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1016/j.meegid.2024.105705
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.23