Nucleotide receptor P2X7/STAT6 pathway regulates macrophage M2 polarization and its application in CAR-T immunotherapy
Silencing P2X7 receptor can reverse M2 macrophage polarization by suppressing STAT6 activation, thereby enhancing the anti-tumor efficacy of CAR-T cells targeting nfP2X7 receptor in OC cell lines.
Authors
- Ruifang Bu
- Na Cui (ORCID: https://orcid.org/0000-0003-1128-9228)
- Si Qin (ORCID: https://orcid.org/0000-0002-0863-9699)
- Hui Liu (ORCID: https://orcid.org/0000-0003-0287-7423)
- Jie Liu (ORCID: https://orcid.org/0000-0002-9685-5825)
- Lu Yang
Institutions
- Inner Mongolia University (CN)
- Second Affiliated Hospital of Inner Mongolia Medical University (CN)
- Inner Mongolia People's Hospital (CN)
- Inner Mongolia International Mongolian Hospital (CN)
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- Immunobiology
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1016/j.imbio.2024.152863
- Citations
- 6
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 2.41