Pathological characterization of lung fibrosis in Sprague–Dawley rats treated with fluoro-edenite fibres by intrapleural injection
This study confirmed that FE exposure promotes the onset of fibrotic lesions at pleural level, as fibrous plaques or nodules and fibrosis, through a mechanism similar to other form of asbestos. These results combined with epidemiological study reported in Biancavilla residents, corroborate the need to promote health and epidemiological surveillance plans of respiratory diseases in population living in FE contaminated sites.
Authors
- Lucia Fazzo (ORCID: https://orcid.org/0000-0002-6465-1780)
- Eva Tibaldi (ORCID: https://orcid.org/0000-0003-1246-4374)
- Federica Gnudi (ORCID: https://orcid.org/0000-0002-4591-5699)
- Caterina Bruno (ORCID: https://orcid.org/0000-0002-5995-4592)
- Daniele Mandrioli (ORCID: https://orcid.org/0000-0001-6156-6516)
- Amerigo Zona (ORCID: https://orcid.org/0000-0002-4639-8662)
- Pietro Comba
Institutions
- Istituto Superiore di Sanità (IT)
- Istituto Ramazzini (IT)
Publication Details
- Journal
- Journal of Occupational Medicine and Toxicology
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1186/s12995-024-00434-5
- Primary Topic
- Inhalation and Respiratory Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Istituto Nazionale per l'Assicurazione Contro Gli Infortuni sul Lavoro