CD34+CLDN5+ tumor associated senescent endothelial cells through IGF2-IGF2R signaling increased cholangiocellular phenotype in hepatocellular carcinoma
Together, our findings illustrated that tumor associated senescent ECs in HCC recruited the MSCs into TME, enhancing cancer stem cell (CSC)-like features of HCC cells and contributing to the CCA formation.
Authors
- Zhipeng Han (ORCID: https://orcid.org/0000-0002-0698-6726)
- Wei Yu (ORCID: https://orcid.org/0000-0001-6817-9076)
- Chen Zong (ORCID: https://orcid.org/0000-0002-8376-7930)
- Lixin Wei (ORCID: https://orcid.org/0000-0002-9526-5348)
- Zhemin Shen (ORCID: https://orcid.org/0000-0002-8043-5228)
- Dong Zhou (ORCID: https://orcid.org/0000-0003-1981-8745)
- Min Hui Tao (ORCID: https://orcid.org/0009-0000-1441-3891)
- Shuping Qu (ORCID: https://orcid.org/0000-0001-7086-1541)
- Li Zhang (ORCID: https://orcid.org/0000-0003-1094-2192)
- Wenting Liu (ORCID: https://orcid.org/0000-0003-1461-3740)
- Hua Bai (ORCID: https://orcid.org/0000-0003-1979-3760)
- Xue Yang (ORCID: https://orcid.org/0000-0003-1303-3306)
- Qiudong Zhao (ORCID: https://orcid.org/0000-0002-3884-2575)
- Xinyu Zhu (ORCID: https://orcid.org/0000-0002-1805-7203)
- Jinghua Jiang
- Mengmeng Xue
- Lu Gao (ORCID: https://orcid.org/0009-0001-3355-7265)
- Xiaojuan Hou
Institutions
- Second Military Medical University (CN)
- National Cancer Center (US)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
- Changhai Hospital (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1016/j.jare.2024.12.008
- Citations
- 9
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.57
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- State Administration of Traditional Chinese Medicine of the People's Republic of China
- Shanghai Municipal Health Bureau
- Shanghai Clinical Research Center