Gut microbiota diversity repeatedly diminishes over time following maintenance infliximab infusions in paediatric IBD patients
We found a recurring reduction over time in alpha diversity following the initial increase in diversity after an IFX infusion. Changes in an individual's microbiome may be an early sign of increasing disease activity that precedes clinical symptoms and increased FC.
Authors
- Katrine Carlsen (ORCID: https://orcid.org/0000-0002-3175-3529)
- Corinna Bang (ORCID: https://orcid.org/0000-0001-6814-6151)
- Louise B. Thingholm (ORCID: https://orcid.org/0000-0002-0266-4375)
- Vibeke Wewer (ORCID: https://orcid.org/0000-0001-9116-9458)
- Mikkel Malham (ORCID: https://orcid.org/0000-0002-6956-7676)
- Astrid Dempfle (ORCID: https://orcid.org/0000-0002-2618-3920)
- Andre Franke
Institutions
- Hvidovre Hospital (DK)
- Copenhagen University Hospital (DK)
- Christian-Albrechts-Universität zu Kiel (DE)
- University Hospital Schleswig-Holstein (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1371/journal.pone.0311604
- Citations
- 6
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Deutsche Forschungsgemeinschaft