Dynamics of Immune Reconstitution and Impact on Outcomes across CAR-T Cell Products in Large B-cell Lymphoma
This study reveals differences in IR patterns after CAR-T therapy in patients with large B-cell lymphoma, with early NK cell recovery emerging as a key predictor of survival. These findings provide potential future avenues of research for improving patient outcomes and tailoring post-therapy management strategies to mitigate relapse risk.
Authors
- Efrat Luttwak (ORCID: https://orcid.org/0000-0003-0212-2135)
- Gunjan L. Shah (ORCID: https://orcid.org/0000-0002-9977-0456)
- Magdalena Corona (ORCID: https://orcid.org/0000-0002-6553-0171)
- Giulio Cassanello (ORCID: https://orcid.org/0000-0002-2192-9930)
- Susan DeWolf (ORCID: https://orcid.org/0000-0002-2754-3537)
- Roni Shouval (ORCID: https://orcid.org/0000-0001-9827-8032)
- Michael Scordo (ORCID: https://orcid.org/0000-0002-9484-0240)
- Danny Luan (ORCID: https://orcid.org/0000-0002-1167-1307)
- Maria Lia Palomba (ORCID: https://orcid.org/0000-0001-5099-9156)
- Kai Rejeski (ORCID: https://orcid.org/0000-0003-3905-0251)
- Caleb A. Lareau (ORCID: https://orcid.org/0000-0003-4179-4807)
- Katharine C. Hsu (ORCID: https://orcid.org/0000-0003-2827-5324)
- Sandeep S. Raj (ORCID: https://orcid.org/0000-0003-4629-0528)
- Alfredo Rivas‐Delgado (ORCID: https://orcid.org/0000-0003-0385-3415)
- Allison Parascondola
- Mohammad Alhomoud (ORCID: https://orcid.org/0000-0003-4552-0109)
- Alejandro Luna (ORCID: https://orcid.org/0000-0003-2201-3091)
- Miguel‐Angel Perales (ORCID: https://orcid.org/0000-0002-5910-4571)
- Gilles Salles (ORCID: https://orcid.org/0000-0002-9541-8666)
- Teng Fei (ORCID: https://orcid.org/0000-0001-7888-1715)
- Jae H. Park (ORCID: https://orcid.org/0000-0002-2903-5130)
- Evangelos Ntrivalas (ORCID: https://orcid.org/0000-0002-3331-1070)
- Marina Gomez-Llobell (ORCID: https://orcid.org/0000-0003-0354-2174)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- University of Milan (IT)
- Cornell University (US)
- Hospital General Universitario Gregorio Marañón (ES)
- LMU Klinikum (DE)
- Hospital Universitario Ramón y Cajal (ES)
- Weill Cornell Medicine (US)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Blood Cancer Discovery
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1158/2643-3230.bcd-24-0163
- Citations
- 8
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 2.26
Funders
- Gilead Sciences
- Memorial Sloan-Kettering Cancer Center
- Swim Across America
- Fundación Española de Hematología y Hemoterapia
- National Institutes of Health
- National Cancer Institute