Phase II Study of Sunitinib in Tumors With <i>c-KIT</i> Mutations: Results From the NCI MATCH ECOG-ACRIN Trial (EAY131) Subprotocol V
Sunitinib for <i>c-KIT</i> mutations did not meet the primary end point, but in this small sample size, a potential signal cannot be ruled out. Rate of eligible <i>c-KIT</i> mutations was low, affecting accrual to this arm.
Authors
- Alice P. Chen (ORCID: https://orcid.org/0000-0002-2919-4326)
- P. Mickey Williams
- Lyndsay N. Harris (ORCID: https://orcid.org/0000-0002-9774-6719)
- Keith T. Flaherty (ORCID: https://orcid.org/0000-0002-3402-0478)
- Peter James O'Dwyer (ORCID: https://orcid.org/0000-0002-9302-4073)
- Larry Rubinstein (ORCID: https://orcid.org/0000-0002-9720-9737)
- James A. Zwiebel (ORCID: https://orcid.org/0000-0003-4455-8789)
- David R. Patton (ORCID: https://orcid.org/0000-0003-3855-0166)
- Lisa M. McShane (ORCID: https://orcid.org/0000-0001-8195-3206)
- Carlos L. Arteaga (ORCID: https://orcid.org/0000-0003-0870-9586)
- Barbara A. Conley (ORCID: https://orcid.org/0000-0002-1445-1684)
- Lilian T. Gien (ORCID: https://orcid.org/0000-0002-6558-3337)
- James V. Tricoli (ORCID: https://orcid.org/0000-0003-3975-8516)
- Robert J. Gray (ORCID: https://orcid.org/0000-0002-5724-4917)
- Stanley R. Hamilton (ORCID: https://orcid.org/0000-0002-8331-1052)
- Andrew Poklepovic (ORCID: https://orcid.org/0000-0002-4015-5037)
- Zihe Song
- Victoria Wang (ORCID: https://orcid.org/0000-0003-4079-5576)
- Eric A. Collisson (ORCID: https://orcid.org/0000-0002-2829-355X)
Institutions
- City Of Hope National Medical Center (US)
- Sunnybrook Health Science Centre (CA)
- Virginia Commonwealth University (US)
- Health Sciences Centre (CA)
- Massachusetts General Hospital (US)
- Fred Hutch Cancer Center (US)
- Southwestern Medical Center (US)
- ECOG-ACRIN Cancer Research Group (US)
- Dana-Farber Cancer Institute (US)
- Frederick National Laboratory for Cancer Research (US)
- National Cancer Institute (US)
- Harold C. Simmons Comprehensive Cancer Center
- University of Pennsylvania (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1200/po-24-00514
- Primary Topic
- Gastrointestinal Tumor Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American College of Radiology Imaging Network
- Margaret A. Cargill Foundation
- ECOG-ACRIN Cancer Research Group
- National Institutes of Health
- National Cancer Institute