Clinical Utility of a Circulating Tumor Cell–Based Cerebrospinal Fluid Assay in the Diagnosis and Molecular Analysis of Leptomeningeal Disease in Patients With Advanced Non–Small Cell Lung Cancer
We detected higher sensitivity to diagnose LMD using CSF CTC-based assay; 38% of LMD cases identified using this assay were missed by standard CSF cytology. CSF molecular testing using CSF cfDNA demonstrated high concordance with tissue-based molecular testing.
Authors
- Ravi Salgia (ORCID: https://orcid.org/0000-0001-9643-7626)
- Isa Mambetsariev (ORCID: https://orcid.org/0000-0003-2882-0249)
- Erminia Massarelli (ORCID: https://orcid.org/0000-0001-7798-7286)
- Shaira Therese Dingal
- Razmig Babikian
- Jyoti Malhotra (ORCID: https://orcid.org/0000-0001-8586-0234)
- Jeremy Fricke (ORCID: https://orcid.org/0000-0003-4684-8114)
- Lisa R. Feldman (ORCID: https://orcid.org/0000-0003-3747-988X)
- Michelle Afkhami (ORCID: https://orcid.org/0000-0001-5830-6158)
- Ramya Muddasani (ORCID: https://orcid.org/0000-0002-2651-8276)
- Amanda Reyes (ORCID: https://orcid.org/0009-0001-4019-3084)
- Pauline Kim
- Mike Chen
Institutions
- City of Hope (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1200/po-24-00373
- Citations
- 4
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 1.14