Relationship Between Insulin Resistance and Monocyte Count by Nutritional Status

Objective: to analyze the relationship between insulin resistance and monocyte count by nutritional status. Methods: analytical cross-sectional study, carried out at the Family Medicine Unit No. 80 in Morelia, Michoacán. Forty-five adults of both genders aged 18-55 years were selected by non-probabilistic sampling. Anthropometry, blood collection for blood biometry, blood chemistry, and insulin receptor expression in monocytes were performed. Patients with chronic diseases and altered immunocompromised states were excluded. Six groups were studied according to body mass index category, and with/without insulin resistance (IR). Median, minimum-maximum value was used. For comparisons between groups, the Kruskal-Wallis test, and Dunn’s multiple comparison test were used as post-hoc. Statistical significance was considered with p<0.05. Results: in adults with normal weight (n= 19), 63% presented IR. There was no difference in the number of classical, intermediate, and non-classical monocytes in patients with insulin resistance (p>0.05). No differences were identified in the expression of the insulin receptor in monocyte populations (p>0.05). Conclusion: a high proportion of insulin resistance was found in individuals with normal weight. Future studies are proposed on the influence of insulin resistance on intracellular signaling and secretion of proinflammatory cytokines derived from different monocyte subtypes in individuals with and without IR.