Macrophage P2Y12 regulates iron transport and its inhibition protects against atherosclerosis
P2Y12 inhibition decreased hepcidin autocrine through repressing NF-κB p65 phosphorylation in macrophages, preventing intracellular iron retention and atherosclerosis.
Authors
- Jiamei Wang (ORCID: https://orcid.org/0000-0003-3724-0561)
- Zhiqing He (ORCID: https://orcid.org/0000-0001-8363-1286)
- Yue Wu (ORCID: https://orcid.org/0009-0004-6801-9899)
- Chun Liang (ORCID: https://orcid.org/0000-0002-4042-206X)
- Hong-Min You
- Xiangyu Shen
- Ya-Sha Chen
- W. Yue (ORCID: https://orcid.org/0009-0001-7483-760X)
- Bowen Hu (ORCID: https://orcid.org/0000-0003-0908-4565)
- Meirong Bai (ORCID: https://orcid.org/0000-0002-5919-7464)
- Qing Jing (ORCID: https://orcid.org/0000-0001-9834-1214)
- Fangfang Li (ORCID: https://orcid.org/0009-0007-2789-1981)
- Tao Xia (ORCID: https://orcid.org/0000-0002-7593-8517)
- Yang-Xi Hu
Institutions
- Second Military Medical University (CN)
- Shanghai Jiao Tong University (CN)
- XinHua Hospital (CN)
- Shanghai Institute of Nutrition and Health (CN)
- Shanghai Changzheng Hospital (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- Changhai Hospital (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1016/j.jare.2024.12.019
- Citations
- 5
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.79
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China