Methodological review to develop a list of bias items for adaptive clinical trials: Protocol and rationale
This review does not require ethics approval as human subjects are not involved. As mentioned previously, this study is the first step in developing a tool to evaluate the risk of bias and methodological quality of ACTs. The findings of this review will inform a Delphi study and the development of a risk of bias tool for ACTs. We plan on publishing this review in a peer-reviewed journal and to present these findings at international scientific conferences.
Authors
- Sameer Parpia (ORCID: https://orcid.org/0000-0002-9407-5622)
- Carole Lunny (ORCID: https://orcid.org/0000-0002-7825-6765)
- Michael Au (ORCID: https://orcid.org/0000-0002-5015-701X)
- Tyler McKechnie (ORCID: https://orcid.org/0000-0002-7668-4096)
- Jesse D. Pasternak (ORCID: https://orcid.org/0000-0002-4342-9080)
- Phillip Staibano (ORCID: https://orcid.org/0000-0002-9095-9543)
- Michael K. Gupta (ORCID: https://orcid.org/0000-0002-1075-2893)
- Keean Nanji (ORCID: https://orcid.org/0000-0002-7176-6631)
- Alex Thabane (ORCID: https://orcid.org/0000-0002-1516-9584)
- Mohit Bhandari (ORCID: https://orcid.org/0000-0001-9608-4808)
- Han Zhang (ORCID: https://orcid.org/0000-0002-7633-6171)
- JEM Young
- Daniel Olteanu (ORCID: https://orcid.org/0009-0002-6819-9995)
Institutions
- University Health Network (CA)
- University of British Columbia (CA)
- University of Toronto (CA)
- Cochrane (CA)
- Impact (CA)
- Hamilton Health Sciences (CA)
- McMaster University (CA)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1371/journal.pone.0303315
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 0.00