Interpreting high levels of unfolded Von Willebrand Factor in patients with the antiphospholipid syndrome
We found that APS patients have high levels of unfolded VWF in their circulation. In APS, auto-antibodies against-β2-GPI may interfere with the β2-GPI-mediated inhibition of VWF-platelet interaction. Therefore, the higher unfolded VWF levels in APS could in part explain the association of APS and thrombotic complications.
Authors
- Marisa Ninivaggi (ORCID: https://orcid.org/0000-0002-3133-1596)
- Shengshi Huang (ORCID: https://orcid.org/0000-0003-2894-8058)
- Hugo Ten Cate (ORCID: https://orcid.org/0000-0001-7796-4463)
- Katrien Devreese (ORCID: https://orcid.org/0000-0002-7559-2579)
- Bas de Laat (ORCID: https://orcid.org/0000-0001-9596-1944)
- Romy de Laat‐Kremers
Institutions
- Ghent University Hospital (BE)
- Ghent University (BE)
- Maastricht University (NL)
- Synapse (Netherlands) (NL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-12
- DOI
- https://doi.org/10.3389/fimmu.2024.1514433
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00