Clinical Outcomes of Gestational Trophoblastic Neoplasia Patients Treated in a Tertiary Care Centre

Gestational Trophoblastic Neoplasia (GTN) is a rare but highly curable condition arising from abnormal placental tissue. This retrospective study, conducted at Calicut Medical College, Kerala, from 2016 to 2019, evaluated the clinical and demographic profile, treatment outcomes, and fertility impacts in 25 patients diagnosed with GTN. Most patients were aged 20 - 35 years, with multiparous women showing a higher risk. Complete hydatidiform mole was the most common histopathological finding (60%), and 84% of patients were diagnosed at an early stage. Low - risk GTN cases responded well to single - agent chemotherapy, primarily Methotrexate, with a 100% treatment success rate. High - risk cases required more intensive regimens and occasional surgical interventions. Fertility outcomes were promising, with 72% of patients able to conceive post - treatment, though many experienced anxiety and depression during care. This study highlights the need for early diagnosis, effective treatment, and comprehensive psychosocial support to optimize outcomes for GTN patients. Further research is needed to explore long - term effects and improve awareness of this condition.