Interleukin-17A facilitates tumor progression <i>via</i> upregulating programmed death ligand-1 expression in hepatocellular carcinoma
IL-17A upregulates PD-L1 expression <i>via</i> the IL-17A receptor/phosphorylation-small mothers against decapentaplegic 2 signaling pathway in HCC cells. Blocking IL-17A enhances the therapeutic efficacy of PD-L1 antibodies in HCC <i>in vivo</i>.
Authors
- Xiaojun Liu (ORCID: https://orcid.org/0000-0003-3399-3486)
- Liting Zhang (ORCID: https://orcid.org/0000-0003-3007-1507)
- Zhixiong Yang (ORCID: https://orcid.org/0000-0002-8362-6644)
- Xuebin Peng
- Xiaorong Mao (ORCID: https://orcid.org/0000-0002-6072-679X)
Institutions
- Lanzhou University (CN)
Publication Details
- Journal
- World Journal of Gastrointestinal Oncology
- Published
- 2024-12-11
- DOI
- https://doi.org/10.4251/wjgo.v17.i1.97831
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.57