AFP shields hepatocellular carcinoma from macrophage phagocytosis by regulating HuR-mediated CD47 translocation in cellular membrane
AFP enhanced CD47 membrane translocation by interacting with HuR. These findings proved that AFP could inhibit macrophage to phagocytize HCC cells by upregulating the localization of CD47 on the HCC cell surface. Combination of AFP with CD47 blockade may be a potential therapeutic strategy for HCC treatment.
Authors
- Mengsen Li (ORCID: https://orcid.org/0000-0003-2512-0386)
- Mingyue Zhu (ORCID: https://orcid.org/0000-0001-5997-4991)
- Qiushi Yin
- Bo Lin (ORCID: https://orcid.org/0000-0002-2108-2696)
- Jiangzheng Zeng (ORCID: https://orcid.org/0000-0002-2382-3961)
- Wei Li (ORCID: https://orcid.org/0000-0003-0132-4819)
- Kun Liu (ORCID: https://orcid.org/0000-0002-7276-7935)
- Gang Wu (ORCID: https://orcid.org/0000-0002-4526-2034)
- Zhaoliang Wang (ORCID: https://orcid.org/0000-0002-4028-0698)
- Xiaowei Li (ORCID: https://orcid.org/0009-0004-2060-7384)
- Yinglian Pan
- Jinchen Liu
Institutions
- Hainan Medical University (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1016/j.tranon.2024.102240
- Citations
- 5
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.20