An ultra-early, transient interferon-associated innate immune response associates with protection from SARS-CoV-2 infection despite exposure
This work was supported by the NIHR Health Protection Research Unit in Respiratory Infections, United Kingdom, NIHR Imperial College London, United Kingdom (Grant number: NIHR200927; AL) in partnership with the UK Health Security Agency and the NIHR Medical Research Council (MRC), United Kingdom (Grant number: MR/X004058/1). Support for sequencing was provided by the Imperial BRC Genomics Facility which is funded by the NIHR, United Kingdom. The development of the hybrid DABA assay used for quantification of SARS-CoV-2 anti-Spike RBD antibodies was supported by the MRC (MC_PC_19078).
Authors
- Kieran Madon (ORCID: https://orcid.org/0000-0002-0146-2560)
- Myra O. McClure (ORCID: https://orcid.org/0000-0002-5494-407X)
- Robert Varro (ORCID: https://orcid.org/0000-0001-5526-225X)
- Sean Nevin
- Seran Hakki (ORCID: https://orcid.org/0000-0003-0554-339X)
- Richard S. Tedder (ORCID: https://orcid.org/0000-0002-9672-5721)
- Aleksandra Koycheva
- Timesh D Pillay (ORCID: https://orcid.org/0000-0001-8608-8880)
- Emily Conibear (ORCID: https://orcid.org/0000-0002-3445-6992)
- John S. Tregoning (ORCID: https://orcid.org/0000-0001-8093-8741)
- Nieves Derqui (ORCID: https://orcid.org/0000-0003-2407-3362)
- Graham P. Taylor (ORCID: https://orcid.org/0000-0002-3773-2390)
- Romain Derelle (ORCID: https://orcid.org/0000-0002-1551-2530)
- Ryan S. Thwaites (ORCID: https://orcid.org/0000-0003-3052-2793)
- Jakob Jonnerby (ORCID: https://orcid.org/0009-0001-7862-8645)
- Ajit Lalvani (ORCID: https://orcid.org/0000-0002-2396-246X)
- Samuel Baldwin (ORCID: https://orcid.org/0009-0009-1838-1319)
- Anjna Badhan (ORCID: https://orcid.org/0000-0001-7375-0433)
- Eleanor Parker (ORCID: https://orcid.org/0000-0002-9898-8568)
- Mica Tolosa-Wright (ORCID: https://orcid.org/0000-0002-3501-9786)
- Carolina Rosadas (ORCID: https://orcid.org/0000-0002-3922-5667)
- Lulu Wang (ORCID: https://orcid.org/0009-0009-7437-5968)
- Joe Fenn (ORCID: https://orcid.org/0000-0003-1166-7831)
- Constanta Luca
- Rhia Kundu
Institutions
- NIHR Imperial Biomedical Research Centre (GB)
- Imperial College London (GB)
Publication Details
- Journal
- EBioMedicine
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1016/j.ebiom.2024.105475
- Citations
- 9
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 3.50
Funders
- National Institute for Health Research Health Protection Research Unit
- National Institute for Health and Care Research
- Imperial College London
- Medical Research Council