DNA methylation-based analysis reveals accelerated epigenetic aging in giant cell-enriched adult-type glioblastoma
With its sped-up epigenetic aging, gcGB presented as the epigenetic oldest GB variant in our cohort. Whereas the correlation between accelerated tumor-intrinsic epigenetic aging and cellular senescence in gcGB stays elusive, fostering epigenetic aging programs in GB might be of interest for future exploration of alternative treatment options in GB patients.
Authors
- Patrick N. Harter (ORCID: https://orcid.org/0000-0001-5530-6910)
- Philipp Jurmeister (ORCID: https://orcid.org/0000-0001-7745-3794)
- Tim R. Fenton (ORCID: https://orcid.org/0000-0002-4737-8233)
- Pia S. Zeiner (ORCID: https://orcid.org/0000-0001-6626-9211)
- Iris Divé (ORCID: https://orcid.org/0000-0003-1096-5626)
- Pinar Cakmak
- Marcus Czabanka (ORCID: https://orcid.org/0000-0001-8709-035X)
- Joachim P. Steinbach (ORCID: https://orcid.org/0000-0002-4695-2483)
- Katharina Johanna Weber (ORCID: https://orcid.org/0000-0001-9395-8944)
- Karl H. Plate
Institutions
- Goethe University Frankfurt (DE)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Southampton General Hospital (GB)
- University Hospital Frankfurt (DE)
- Frankfurt Cancer Institute (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1186/s13148-024-01793-w
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Dr. Senckenbergische Stiftung