Effect of bovine prostate extract on the contractile activity of lymphatic vessels in rats

Introduction. A comprehensive approach to treatment of chronic prostatitis, representing a widespread and poorly treatable disease, includes the use of antibacterial, anti-inflammatory medicines, etc. In this context, a promising approach to the treatment of chronic prostatitis involves the use of bioregulatory peptides isolated from bovine prostate tissue. Objective. To study the effect of cattle prostate extract containing bioregulatory peptides on the functional activity of lymphatic vessels. Ма terials and methods. The study was performed on isolated lymphatic vessels of rats. The range of studied concentrations of the substance was 2–10 µg/ mL (in terms of water-soluble peptides). Results. Bioregulatory peptides included into the prostate extract impacts the vasomotor activity of lymphatic vessels. In the range of studied concentrations (2–10 µg/ml), the substance has a stimulating effect on lymphangion motility. This is realized by increasing the rate of lymphatic vessel contractions, which effect is most pronounced at the concentration of 5 µg/ml as a 37.6% ( p ≤ 0.05) of base level. The obtained stimulating effect is stable during 30-min “washing” of lymphatic vessels with physiological solution. Conclusions. Water-soluble bioregulatory peptides contained in the extract of cattle prostate and having organotropic action on the prostate gland may contribute to the reduction of tissue edema by activating the motility of pelvic lymphatic vessels.