Heterogeneity in Pancreatitis
Both the clinical management and study of recurrent acute pancreatitis and chronic pancreatitis are complicated by significant heterogeneity in the etiology, mechanisms, symptoms, and complications of pancreatitis. The National Institutes of Diabetes and Digestive and Kidney Disease recently convened a workshop to address current knowledge and knowledge gaps in the field. Preclinical models that better replicate human disease are important for development of new therapies. Pain is often the most common and most difficult symptom to treat, as the causes are multifactorial and effective treatment may vary depending on whether pain is neuropathic or nociceptive in origin, and the placebo effect can complicate evaluation of the efficacy of medical and procedural interventions. Novel technologies like functional magnetic resonance imaging and virtual reality may offer novel means for assessing and treating pain, respectively. Clinical trial designs will need to consider best approaches to addressing the heterogeneity of chronic pancreatitis, including careful attention to designing eligibility criteria, and establishing accepted and validated core outcomes criteria for the field. The latter may be informed by consensus in pain research. Recruitment of participants into clinical trials has been challenging, often requiring multiple centers. Establishment of a clinical trials network would facilitate greater opportunities for therapeutic trials in pancreatitis.
Authors
- Melena D. Bellin (ORCID: https://orcid.org/0000-0002-7324-4837)
- Linda Gore Martin (ORCID: https://orcid.org/0009-0004-7696-5068)
- Donald E. Born (ORCID: https://orcid.org/0000-0001-6102-512X)
- David C. Whitcomb (ORCID: https://orcid.org/0000-0002-4462-1410)
- Steven J. Hughes (ORCID: https://orcid.org/0000-0002-5688-6942)
- Venkata Sandeep Akshintala (ORCID: https://orcid.org/0000-0002-8909-1951)
- Jeffrey J. Easler (ORCID: https://orcid.org/0000-0002-3772-2803)
- Dhiraj Yadav (ORCID: https://orcid.org/0000-0001-7078-9893)
- Evan L. Fogel (ORCID: https://orcid.org/0000-0003-0998-8257)
- Georgios I. Papachristou (ORCID: https://orcid.org/0000-0001-9915-703X)
- Amy Jensen
- Stephen J. Pandol (ORCID: https://orcid.org/0000-0003-0818-6017)
- Tonya M. Palermo (ORCID: https://orcid.org/0000-0001-6036-6715)
- Frederico G. S. Toledo (ORCID: https://orcid.org/0000-0002-6570-9948)
- Anna Evans Phillips (ORCID: https://orcid.org/0000-0001-6154-5651)
- Christopher E. Forsmark (ORCID: https://orcid.org/0000-0002-2508-1543)
- Jill M. VanDalfsen
- Dana K. Andersen (ORCID: https://orcid.org/0000-0002-9714-8671)
- Omer Liran (ORCID: https://orcid.org/0000-0001-6175-3936)
- Bechien Wu
- Walter G. Park (ORCID: https://orcid.org/0000-0001-8187-4188)
- Robert C. Coghill (ORCID: https://orcid.org/0000-0003-3828-1605)
- A. Jay Freeman (ORCID: https://orcid.org/0000-0002-3399-3390)
- Vikesh K. Singh
- Sarah Jane Schwarzenberg
Institutions
- Cedars-Sinai Medical Center (US)
- Cincinnati Children's Hospital Medical Center (US)
- National Institutes of Health (US)
- Fairview Health Services (US)
- Nationwide Children's Hospital (US)
- College Board (US)
- Kaiser Permanente (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Cystic Fibrosis Foundation (US)
- University of Florida Health (US)
- The Ohio State University Wexner Medical Center (US)
- University of Florida (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- Seattle Children's Hospital (US)
- University of Pittsburgh Medical Center (US)
- University of Minnesota Children's Hospital (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Stanford University (US)
Publication Details
- Journal
- Pancreas
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1097/mpa.0000000000002403
- Citations
- 4
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.29