Amomum villosum Lour. alleviates pre-eclampsia by inducing enrichment of Bifidobacterium bifidum through vanillic acid to inhibit placental ferroptosis
This research is the first to demonstrate that WOA prevents PE by enriching Bifidobacterium bifidum, strengthening the gut-placenta barrier, and inhibiting placental ferroptosis. Our findings provide compelling evidence for the vital involvement of the gut-placental axis in the protection of AVL on PE, presenting a novel target for the clinic.
Authors
- Chang Su (ORCID: https://orcid.org/0000-0003-1285-3724)
- Jie Zhao (ORCID: https://orcid.org/0000-0002-7751-4435)
- Jiahan Wang (ORCID: https://orcid.org/0009-0006-5115-6939)
- Bing Wang (ORCID: https://orcid.org/0000-0002-7078-4352)
- Peishi He
- Yarui Liu (ORCID: https://orcid.org/0000-0001-8336-2426)
- Shuhong Wang (ORCID: https://orcid.org/0000-0001-7624-478X)
- Haoqing He
- Yun Wu
Institutions
- Guangdong Pharmaceutical University (CN)
- Tsumura Research Institute (Japan) (JP)
- Zhujiang Hospital (CN)
- Shenzhen Institute for Drug Control (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1016/j.jep.2024.119217
- Citations
- 10
- Primary Topic
- Pregnancy and Medication Impact
- Type
- article
- Field-Weighted Citation Impact
- 5.43
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province