Polymers Facilitating Therapeutic Efficacy and Applications for Traditional Chinese Medicine

ABSTRACT The active ingredients from traditional Chinese medicine (TCM) are fundamental to its therapeutic efficacy. However, their difficult detection, low solubility, poor stability, uncertain biocompatibility, and inefficient absorption rate, hinder their clinical application. Polymers have emerged as a viable solution to these issues, providing a platform for the detection, enrichment, and exertion of pharmacological effects. This review delves into the application of polymers in active ingredients from TCM, covering various aspects including molecularly imprinted polymers (MIPs), polymer micelles, polymer hydrogels, conjugated polymers, and polymer nanoparticles (NPs). These advanced systems leverage the designability, adjustable solubility, and biocompatibility of polymers to enhance the therapeutic potential of TCM. The review concludes by discussing the current challenges and prospects of using polymers in TCM. It aims to provide a comprehensive understanding of the field, highlighting the potential of polymers to revolutionize TCM practices and contribute to the modernization of TCM.