Seraph-100 hemoperfusion for management of severe COVID-19: Assessment of serum and plasma analytes pre- and post-filtration
Initial freely circulating SARS-CoV-2 RNA levels of ICU-admitted subjects were low or undetectable. The Seraph 100 filter did not significantly reduce viral RNA titers in their plasma. However, multiple circulating proteins with roles in inflammation, endothelial/epithelial damage, and/or angiogenesis decreased significantly across the filter. Larger prospective trials will be required to determine if such transient reductions translate into improved patient outcomes. However, this study did not demonstrate a direct reduction of free SARS-CoV-2 viral RNA by the Seraph 100.
Authors
- Michael J. Rouse (ORCID: https://orcid.org/0000-0003-0640-9184)
- Sarah A. Jenkins (ORCID: https://orcid.org/0000-0002-6774-6929)
- Joost Brandsma (ORCID: https://orcid.org/0000-0003-2914-3403)
- Danielle V. Clark (ORCID: https://orcid.org/0000-0003-2752-3621)
- Ian J. Stewart (ORCID: https://orcid.org/0000-0001-6653-875X)
- Eliot Gann (ORCID: https://orcid.org/0000-0001-5570-8880)
- Jeffrey Della Volpe
- Caroline Park (ORCID: https://orcid.org/0000-0002-1763-972X)
- Victor A. Sugiharto (ORCID: https://orcid.org/0000-0002-9505-7303)
- Kathleen P. Pratt (ORCID: https://orcid.org/0000-0001-6837-6133)
- Mark P. Simons (ORCID: https://orcid.org/0000-0002-4316-9709)
- Hua‐Wei Chen (ORCID: https://orcid.org/0000-0003-0706-8254)
- Josh Chenoweth (ORCID: https://orcid.org/0009-0003-9693-5010)
- Stephen A. Chitty
- Seth Schobel (ORCID: https://orcid.org/0000-0002-8967-257X)
- Michael Lewis (ORCID: https://orcid.org/0000-0002-1892-4127)
- Amay Parikh (ORCID: https://orcid.org/0000-0002-7332-0625)
- Pooja Vir (ORCID: https://orcid.org/0000-0002-6816-5122)
- Pavol Genzor (ORCID: https://orcid.org/0000-0002-3316-5659)
- H. Thomas Robertson (ORCID: https://orcid.org/0000-0001-6536-3804)
- Ian Rivera
Institutions
- Henry M. Jackson Foundation (US)
- Naval Medical Research Command (US)
- Uniformed Services University of the Health Sciences (US)
- AdventHealth Orlando (US)
- Walter Reed National Military Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Blood Purification
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1159/000542995
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00