Pharmacological PTP1B inhibition rescues motor learning, neuroinflammation, and hyperglycaemia in a mouse model of Alzheimer's disease
We provide evidence that neuronal BACE1 contributes to neuroinflammation and hyperglycaemia in PLB4 mice, and this can be partially rescued by PTP1B inhibition. Targeting PTP1B may therefore offer an attractive therapeutic approach to ameliorate co-morbidity associated pathologies in AD and T2DM.
Authors
- C. L. Hull (ORCID: https://orcid.org/0000-0001-7503-8589)
- Mirela Delibegović (ORCID: https://orcid.org/0000-0001-6193-3152)
- Zara J. Franklin (ORCID: https://orcid.org/0000-0001-6685-5181)
- Bettina Platt (ORCID: https://orcid.org/0000-0002-7852-0749)
Institutions
- Zanjan University of Medical Sciences (IR)
- University of Aberdeen (GB)
- Department of Medical Sciences (RU)
Publication Details
- Journal
- Experimental Neurology
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1016/j.expneurol.2024.115115
- Citations
- 4
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 0.94