Precisely Tailoring Molecular Structure of Doxorubicin Prodrugs to Enable Stable Nanoassembly, Rapid Activation, and Potent Antitumor Effect
These findings underscore the critical role of prodrug molecule design in the development of effective prodrug nanoassemblies. The balance between stability and drug release is pivotal for optimizing drug delivery and maximizing therapeutic efficacy.
Authors
- Cong Luo (ORCID: https://orcid.org/0000-0002-0506-9598)
- Yaxin Zheng (ORCID: https://orcid.org/0000-0002-0141-848X)
- Jinghua Xu (ORCID: https://orcid.org/0000-0002-0036-8900)
- Wenhu Zhou (ORCID: https://orcid.org/0000-0003-3794-661X)
- Chengcheng Feng
- Yuting Wang (ORCID: https://orcid.org/0009-0000-6985-3114)
Institutions
- Shenyang Pharmaceutical University (CN)
- Central South University (CN)
- Changsha Medical University (CN)
Publication Details
- Journal
- Pharmaceutics
- Published
- 2024-12-11
- DOI
- https://doi.org/10.3390/pharmaceutics16121582
- Citations
- 180
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 31.21
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Liaoning Province