BNIP3 Downregulation Ameliorates Muscle Atrophy in Cancer Cachexia
These findings suggest that a fine balance between mitochondrial disposal and biogenesis is fundamental for preserving muscle homeostasis and highlight a potential role for BNIP3 modulation against cancer-induced muscle wasting.
Authors
- Fabio Penna (ORCID: https://orcid.org/0000-0002-2774-6027)
- Paola Costelli (ORCID: https://orcid.org/0000-0003-1216-7230)
- David Sebastián (ORCID: https://orcid.org/0000-0002-7260-3869)
- Claudia Fornelli (ORCID: https://orcid.org/0000-0002-2555-1082)
- Marc Beltrà (ORCID: https://orcid.org/0000-0001-6070-9861)
- António Zorzano (ORCID: https://orcid.org/0000-0002-1638-0306)
Institutions
- Instituto de Salud Carlos III (ES)
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
- Institute for Research in Biomedicine (ES)
- Institut de Biomedicina de la Universitat de Barcelona
- University of Turin (IT)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Cancers
- Published
- 2024-12-11
- DOI
- https://doi.org/10.3390/cancers16244133
- Citations
- 6
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.32
Funders
- Ministero della Salute
- Associazione Italiana per la Ricerca sul Cancro
- Universitat de Barcelona
- National Institutes of Health